Instrumentation

NMR Spectroscopy
Mass Spectrometry

Bruker Avance III HD 400 MHz NMR Spectrometer
- NanoBay console with 2 RF channels
- SampleXpress 60-sample automation robot
- SmartProbe, capable of ¹H{¹⁹F}, ¹⁹F{¹H}, and X{¹H} experiments, with X tunable between ¹⁰⁹Ag and ³¹P (e.g., ⁷Li, ¹¹B, ¹³C, ¹⁴N, ¹⁵N, ¹⁷O, ²³Na, ²⁹Si, ³¹P, ⁷⁷Se, ¹¹⁹Sn)
- ATM (automated tune and match) module
- z-axis pulsed field gradient equipped (hardware and probe)

Varian Unity-Inova 500 MHz NMR Spectrometer
- 3 RF channels
- Waveform generators
- z-axis pulsed field gradient equipped (hardware and all probes)
- Varian triple-resonance, inverse-detection probe, capable of ¹H{¹³C/X} experiments, with X tunable between ¹⁵N and ³¹P
- Varian broadband direct detection probe (default), high band ¹H and ¹⁹F, low band tunable ³¹P ^-15N
- Nalorac MBDG 3mm probe, double ¹³C sensitivity for small amount of samples

Bruker MaXis Ultra-High Resolution Quadrupole Time-of-Flight MS
- Dual ion funnel design for maximal sensitivity
- Capable of resolution >65,000 FWHM for MS and MS/MS
- Mass Accuracy <1 ppm with internal calibration
- Maximum acquisition rate 20 Hz
Bruker UltraFlex MALDI-ToF/ToF
- 2 KHz NdYAG, Smart Beam II laser capable of beam focus to 10 microns with no pixel overlap
- MALDI-MS Imaging through FlexImaging software
- Resolution of 40,000 FWHM
- Mass Accuracy <1 ppm with internal calibration
- Linear and Reflectron modes
Thermo Orbitrap Elite with ETD-High Resolution Orbitrap MS
- Hybrid mass spectrometer with Velos linear ion trap and Orbitrap detectors
- Smaller diameter Orbitrap cell allows resolution up to 240,000 FWHM @ 400 m/z
- Mass Accuracy <1 ppm with internal calibration
- Multiple fragmentation mechanisms available, CID, HCD and ETD
Thermo Orbitrap Q-Exactive MS
- Quadrupole-Orbitrap configuration allows broader mass range, 50-6000 m/z
- Smaller diameter Orbitrap cell allows resolution up to 140,000 FWHM @ 200 m/z
- Mass Accuracy <1 ppm with internal calibration
- Capable of fast polarity switching
- Dynamic range >5000 in 1 scan
AB Sciex Q-Trap 5500
- Turbo ion spray source for maximal sensitivity
- Q3 linear ion trap allows traditional triple quad MRM or MSⁿ
- Automated compound optimization facilitates method development
Dionex UltiMate 3000 RSLC Quaternary System
- Up to 4 solvents available in one run
- Capable of pressures to 15,000 psi
- Flow 0.1 to 8.0 ml/min
- Column temperatures up to 110 Celsius
- Photodiode array UV detector
- Coupled to the Thermo Q-Exactive
Waters Acquity UPLC System
- Capable of pressures to 15,000 psi
- Flow rates from 0.1-2.0 ml/min
- Photodiode array UV detector
- Peak widths <6 sec
- Can couple to Bruker and AB Sciex spectrometers
Waters Nano-Acquity UPLC System
- Capable of pressures to 15,000 psi
- Splitless flow rates from 0.2-200.0 microliters/min
- Can be coupled to Bruker and Thermo instruments

Decommissioned

IonSpec ProMALDI FT Mass Spectrometer
Agilent 1100 HPLC-MSD VL Quadrupole Mass Spectrometer
Agilent 1100 HPLC-MSD SL Quadrupole Mass Spectrometer – APCI Walk-up Instrument
Agilent 1100 HPLC-MSD Ion Trap Mass Spectrometer
Bruker Amazon Ion-Trap